Thermo Fisher Scientific ATF4 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (85%), Rat (86%), Pig (82%), Sheep (82%), Rhesus Monkey (97%), Chimpanzee (98%), Bovine (81%).
• Positive Control: HeLa, HeLa treated with tunicamycin (4 µg/mL).
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a transcription factor originally identified as a widely expressed mammalian DNA-binding protein capable of binding a tax-responsive enhancer element in the LTR of HTLV-1. It was also characterized as the cAMP-response element binding protein 2 (CREB-2).
The encoded protein belongs to a family of DNA-binding proteins that includes AP-1 transcription factors, CREBs, and CREB-like proteins. These factors share a leucine zipper region involved in protein-protein interactions, located C-terminal to a basic amino acid stretch functioning as a DNA-binding domain.
Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 within a region containing a large inverted duplication.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.