Thermo Fisher Scientific PrP Polyclonal Antibody
Human PrP 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제되었으며, 비결합형 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: [참고 문헌 정보 없음]
Immunoprecipitation (IP)
- Tested Dilution: 1–2 µL/mg of lysate
- Publications: [참고 문헌 정보 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human PrP/PRNP fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography, Protein A |
| Storage buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2866901 |
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associated with lipid raft components and functions as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells, and in distribution of junction-associated proteins in human enterocytes. Conversion of the normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with prion neurodegenerative disorders such as Creutzfeld-Jakob disease (CJD). PrPc is rich in alpha-helices, while PrPSc has higher beta-sheet content and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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