Thermo Fisher Scientific GLRB Polyclonal Antibody
Human GLRB 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GLRB. Recombinant protein control fragment (Product # RP-91139) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642040 |
Product Specific Information
Immunogen sequence:
MLNNPKRVEA EKARIAKAEQ ADGKGGNVAK KNTVNGTGTP VHISTLQVGE TRCKKVCTSK SDLRSNDFSI VGSLPRDFEL SNYDCYGKPI EVNNGLGKSQ AKNNKKPPPA KPVIPTAAK
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 97%
Target Information
In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutyric acid, serotonin, and acetylcholine comprise an evolutionarily conserved superfamily of ligand-gated ion channels.
The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins (alpha1–alpha4 and beta) and an associated peripheral membrane protein, forming a chloride-selective ion channel.
In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca²⁺ in the brainstem and midbrain indicates an important role for Ca²⁺ in modulation of glycinergic synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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