Thermo Fisher Scientific GLRB Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human GLRB. Recombinant protein control fragment (Product #RP-91139). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GLRB,uniProtId:P48167-1,ncbiNodeId:9606,antigenRange:353-471,antigenLength:497,antigenImageFileName:PA5-62593_GLRB_P48167-1_Rabbit.svg,antigenImageFileNamePDP:PA5-62593_GLRB_P48167-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642040

Product Specific Information

Immunogen sequence: MLNNPKRVEA EKARIAKAEQ ADGKGGNVAK KNTVNGTGTP VHISTLQVGE TRCKKVCTSK SDLRSNDFSI VGSLPRDFEL SNYDCYGKPI EVNNGLGKSQ AKNNKKPPPA KPVIPTAAK

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

Target Information

In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutryic acid, serotonin and acetylcholine comprise an evolutionally conserved superfamily of ligand-gated ion channels. The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins, alpha1 through alpha4 and beta, and an associated peripheral membrane protein, which combine to form a chloride-selective ion channel. In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca2+ in the brainstem and midbrain indicate an important role for Ca2+ in modulation of glycinergic synapses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.