Thermo Fisher Scientific TRAF4 Polyclonal Antibody
Human TRAF4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P)에서 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TRAF4. Recombinant protein control fragment (Product # RP-93179) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648873 |
Product Specific Information
Immunogen sequence:
GAFDNLLEWP FARRVTFSLL DQSDPGLAKP QHVTETFHPD PNWKNFQKPG TWRGSLDESS LGFGYPKFIS HQDIRKRNYV RDDAVFIRAA VELPRKI
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine-rich extracellular domains. Members of this family include TNF-RI, TNF-RII, and CD40. Ligands for these receptors can be small secreted proteins such as TNF, or type II integral membrane proteins such as CD40L.
While the signal transduction mechanism of the TNF receptor superfamily is not fully understood, activation of TNF-R or CD40 induces nuclear translocation of NFκB. Members of the TRAF (TNF receptor-associated factor) family are implicated in this process. Four members have been described: TRAF1, TRAF2, TRAF3 (also known as CRAF1, LAP1, or CD40bp), and TRAF4. TRAF4, originally termed CART1, is specifically expressed in breast carcinomas and localized to the nucleus in such tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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