Thermo Fisher Scientific TAB2 Monoclonal Antibody (3B5)

Thermo Fisher Scientific TAB2 Monoclonal Antibody (3B5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15713 targets TAB2 in indirect ELISA, FACS, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human TAB2 expressed in E. coli.
MA5-15713 detects TAB2, which has a predicted molecular weight of approximately 80 kDa.

Target Information

TAB2 is an activator of MAP3K7/TAK1, required for IL-1–induced activation of NF-kappaB and MAPK8/JNK.
It forms a kinase complex with TRAF6, MAP3K7, and TAB1, serving as an adaptor linking MAP3K7 and TRAF6.
TAB2, TAB1, and MAP3K7 participate in TNFSF11/RANKL signal transduction via activation of TNFRSF11A/RANK, regulating osteoclast development and function.
TAB2 and TAB3 interact with autophagy mediator Beclin-1; upon autophagy induction, they dissociate from Beclin-1 and bind TAK1. Overexpression inhibits autophagy, while depletion triggers it, suggesting TAB2 and TAB3 act as control points for autophagy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.