Thermo Fisher Scientific Human CARD10 Synthetic Peptide
인간 CARD10 단백질의 C-말단 14개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-19997의 블로킹 펩타이드로 사용 가능. 정제된 액상 형태로 제공되며 200 µg/mL 농도, PBS(pH 7.2, 0.1% BSA) 용액에 보존. 연구용으로만 사용.
- 카탈로그번호
- PEP0119
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human CARD10.
PEP-0119 can be used as a blocking peptide with polyclonal antibody PA5-19997.
Target Information
CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds assisting assembly of signal transduction molecules.
CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests distinct biological functions in different cell types.
The CARD domain of CARMA3 specifically interacts with BCL10, a protein known to regulate apoptosis and NF-κB activation. When expressed in cells, this protein binds to BCL10 and activates NF-κB.
Recent experiments have shown that CARMA3 is required for EGF-induced NF-κB activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for EGFR-driven tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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