Thermo Fisher Scientific Human CARD10 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the carboxy terminus of human CARD10.
PEP-0119 can be used as a blocking peptide with polyclonal antibody PA5-19997.

Target Information

CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds assisting assembly of signal transduction molecules.
CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests distinct biological functions in different cell types.
The CARD domain of CARMA3 specifically interacts with BCL10, a protein known to regulate apoptosis and NF-κB activation. When expressed in cells, this protein binds to BCL10 and activates NF-κB.
Recent experiments have shown that CARMA3 is required for EGF-induced NF-κB activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for EGFR-driven tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.