Thermo Fisher Scientific Human Lano Synthetic Peptide
인간 Lano 단백질의 C-말단 15 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-19994의 블로킹 펩타이드로 사용 가능. PBS 버퍼에 0.1% BSA 및 0.02% sodium azide 포함. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human Lano.
PEP-0116 can be used as a blocking peptide with polyclonal antibody PA5-19994.
Target Information
Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble. The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells.
Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions.
It has been suggested that through these interactions, LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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