Thermo Fisher Scientific Alpha-2-Macroglobulin Monoclonal Antibody (A2M, 3623)
인간 Alpha-2-Macroglobulin(A2M)을 인식하는 마우스 단클론 항체로, IHC(P) 및 Peptide Array에 사용 가능. 고순도 Protein A/G 정제, 200 µg/mL 농도. 비접합 형태로 PBS/BSA 완충액에 보관, 연구용 전용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A2M, 3623 |
| Immunogen | Human recombinant A2M protein fragment (aa 604–748) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Alpha 2-Macroglobulin (A2M) is an approximately 720-kDa homotetrameric glycoprotein composed of four identical ~180 kDa subunits. A2M shares with other alpha-macroglobulins, such as complement components C3, C4, and pregnancy zone protein (PZP), an extraordinary binding capacity for various ligands. This enables alpha-macroglobulins to function as humoral defense barriers against foreign peptides in plasma. A2M interacts with and captures virtually any proteinase, acting as a panprotease inhibitor. In Alzheimer’s disease (AD) patients, A2M has been localized to diffuse amyloid plaques, suggesting a significant role in AD pathophysiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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