Thermo Fisher Scientific MMP-7 (Matrilysin) Polyclonal Antibody
Rabbit polyclonal antibody targeting human MMP-7 (Matrilysin). Validated for WB and IHC (Paraffin). Suitable for detecting cytoplasmic and extracellular matrix localization. Supplied as liquid, 0.5 mg/mL, purified by antigen affinity chromatography.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of human MMP-7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Conditioned A431 cells
- Cellular location: Cytoplasmic and extracellular matrix
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in pathological processes including arthritis and metastasis. Most MMPs are secreted as inactive proproteins that become active upon cleavage by extracellular proteinases.
MMP-7 specifically degrades proteoglycans, fibronectin, elastin, and casein, and differs from most MMP family members by lacking a conserved C-terminal protein domain. It plays a role in wound healing and may regulate defensin activity in the intestinal mucosa. The MMP7 gene is part of a cluster located on chromosome 11q22.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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