Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI2B8), TrueMAB
MDM4 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간 시료 반응성이 있으며, 고순도 친화 크로마토그래피 정제 제품입니다. PBS/BSA/glycerol buffer에 보관되며 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B8 |
| Immunogen | Full length human recombinant protein of human MDM4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The MDM2 protein is the primary regulator of p53 protein stability.
MDMX (also designated MDM4) is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2.
The gene encoding MDMX is a target for amplification in malignant gliomas.
ARF interacts with MDMX to sequester MDMX within the nucleolus, increasing p53 transactivation.
Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation.
Like MDM2, MDMX also binds p73 and stabilizes its level, increasing the half-life of p73.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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