Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI4B5), TrueMAB
MDM4 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. HEK293T 세포에서 발현된 재조합 단백질을 면역원으로 사용하였으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B5 |
| Immunogen | Full length human recombinant protein of human MDM4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX (also known as MDM4) is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene encoding MDMX is frequently amplified in malignant gliomas. ARF interacts with MDMX to sequester it within the nucleolus, leading to increased p53 transactivation. Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Additionally, MDMX binds p73 and stabilizes its level, increasing the half-life of p73 in contrast to p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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