Thermo Fisher Scientific PARC/H7-AP1 Polyclonal Antibody
PARC/H7-AP1 폴리클로날 항체로 인간 PARC 단백질을 특이적으로 인식. Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체. 4°C에서 보관, 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 1 and 50 of human P53-associated parkin-like cytoplasmic protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large Parkin-like ubiquitin ligase, has been identified as a cytoplasmic anchor protein in p53-associated complexes. Inactivation of PARC results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression promotes cytoplasmic sequestration of p53. Interestingly, PARC knockout mice are viable without obvious phenotype, suggesting redundancy with other cullin family E3 ubiquitin ligases. p53 binding to PARC may regulate PARC function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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