Thermo Fisher Scientific PARC/H7-AP1 Polyclonal Antibody
Rabbit polyclonal antibody against human PARC/H7-AP1 (Cullin 9). Validated for Western blot and immunoprecipitation. Supplied as liquid, 1 mg/mL concentration. Recommended storage at 4°C, for research use only.
- 카탈로그번호
- A300096Ax (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PARC/H7-AP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 1 and 50 of human P53-associated parkin-like cytoplasmic protein (Cullin 9, UniProt ID: Q8IWT3-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
The continued localization of p53 to the nucleus is essential for its tumor suppressor function. PARC (P53-associated parkin-like cytoplasmic protein), a large ubiquitin ligase, acts as a cytoplasmic anchor protein in p53-associated complexes. Inactivation of PARC leads to nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression promotes cytoplasmic sequestration of p53. Interestingly, PARC knockout mice are viable with no obvious phenotype, suggesting functional redundancy with other cullin family E3 ubiquitin ligases. p53 binding to PARC may also regulate PARC activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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