Thermo Fisher Scientific KCNH2 Polyclonal Antibody
KCNH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. IHC(P) 등 다양한 응용 가능. 인간, 설치류, 박쥐 등 여러 종에 반응. 고순도 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
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Thermo Fisher Scientific KCNH2 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from internal region of human KCNH2 / Kv11.1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551235 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Panda, Bat (100%).
Target Information
Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr.
There are two N-terminal splice variants of HERG: the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1 alpha.
Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation.
HERG is expressed in the heart, more abundantly in ventricles than atria. Mutations in HERG increase beat-to-beat variability and early after depolarization, facilitating premature heartbeats associated with long QT syndrome type 2 and short QT syndrome type 1.
주의사항
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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