Thermo Fisher Scientific SGK196 Monoclonal Antibody (OTI4D9), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes a protein involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (α-DG), which forms transmembrane linkages between the extracellular matrix and the cytoskeleton.
Some pathogens use this O-linked carbohydrate unit for host entry. Loss-of-function compound heterozygous mutations in this gene have been associated with the Walker-Warburg syndrome (WWS) phenotype.
Mice lacking this gene exhibit misplaced neurons (heterotopia) in certain brain regions, likely due to defects in neuronal migration. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.