Thermo Fisher Scientific CDK7 Monoclonal Antibody (MO-1)
CDK7 단백질을 인식하는 Thermo Fisher Scientific의 MO-1 단클론 항체. Western blot, IHC, ICC/IF, IP에 적합. Human 시료 반응성, Mouse IgG2b 아이소타입. 고순도 정제, 1 mg/mL 농도, PBS 버퍼에 0.08% sodium azide 포함.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1–10 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Immunoprecipitation (IP) | 1–10 µg/mL | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MO-1 |
| Immunogen | Recombinant 221 amino acid fragment of the C terminus of p40mo15 recognizing a 40 kDa protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073565 |
Target Information
The trimeric complex of CDK7, cyclin H, and MNAT1 functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, which is involved in transcription initiation and DNA repair. This complex serves as a direct link between the regulation of transcription and the cell cycle. The bound complex is important in the normal double-strand break repair function of BRCA1. CDK7 may be a target of germline cancer-inducing mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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