Thermo Fisher Scientific p21 Monoclonal Antibody (DCS-60)
p21 단백질을 인식하는 DCS-60 클론의 마우스 단클론 항체. Western blot, IHC, IP 등 다양한 응용에 사용 가능. Protein A/G로 정제된 액상 항체로 1 mg/mL 농도. p53 경로 연구 및 세포 주기 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | Assay-dependent | View 2 publications |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DCS-60 |
| Immunogen | Full-length recombinant p21 protein (aa 1–164, UniProt ID: P38936-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | –20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1075235 |
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDKs) and is transcriptionally activated by p53. It plays a crucial role in the cellular response to genotoxic stress and is a major transcriptional target of p53.
In the nucleus, p21 binds and inhibits CDK1 and CDK2, blocking the transition from G1 to S phase or G2 to mitosis after DNA damage, allowing DNA repair.
In the cytoplasm, p21 exhibits anti-apoptotic activity by binding to and inhibiting caspase 3, ASK1, and JNK.
p21 has dual functions in carcinogenesis, acting both as a tumor suppressor and as an oncogene depending on context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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