Thermo Fisher Scientific Estrogen Receptor alpha Recombinant Rabbit Monoclonal Antibody (PD00-04)
Human Estrogen Receptor alpha 인식용 재조합 토끼 단클론 항체. IHC(P)에서 1:1,000 희석으로 검증됨. 고순도 Protein A 정제, PBS/BSA/glycerol buffer 구성. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- MA544670
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PD00-04 |
| Immunogen | Synthetic peptide within Human Estrogen Receptor alpha aa 1–50/595 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931128 |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, undergoes a conformational change enabling dimerization and DNA binding to estrogen response elements (ERE). ER can regulate gene transcription positively or negatively through recruitment of coactivator or corepressor proteins.
Two forms exist, alpha and beta, encoded by ESR1 and ESR2 genes. Alternative RNA splicing produces at least four isoforms of estrogen receptor-alpha (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are widely expressed in various tissues, essential for sexual development and reproductive function, and also play roles in bone and other tissues. They are implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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