Thermo Fisher Scientific Estrogen Receptor alpha Recombinant Rabbit Monoclonal Antibody (PD00-04)

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 1:1,000

Product Specifications

Target Information

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, undergoes a conformational change enabling dimerization and DNA binding to estrogen response elements (ERE). ER can regulate gene transcription positively or negatively through recruitment of coactivator or corepressor proteins.

Two forms exist, alpha and beta, encoded by ESR1 and ESR2 genes. Alternative RNA splicing produces at least four isoforms of estrogen receptor-alpha (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are widely expressed in various tissues, essential for sexual development and reproductive function, and also play roles in bone and other tissues. They are implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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