Thermo Fisher Scientific CD20 Recombinant Rabbit Monoclonal Antibody (PD00-02)
Thermo Fisher Scientific의 CD20 Recombinant Rabbit Monoclonal Antibody (PD00-02)는 인간 CD20 단백질을 표적으로 하는 고특이성 항체입니다. IHC(P) 분석에 적합하며, 재조합 단일클론 형식으로 높은 재현성과 순도를 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PD00-02 |
| Immunogen | Synthetic peptide within Human CD20 aa 210–297 (Cytoplasmic) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931130 |
Target Information
CD20 is a non-glycosylated surface phosphoprotein with a molecular weight of 33–37 kDa depending on phosphorylation. It is expressed on mature and most malignant B cells, a subset of T lymphocytes, and follicular dendritic cells. CD20 expression coincides with surface IgM expression and regulates calcium conductance, cell cycle progression, and B-cell proliferation. It associates with lipid rafts, with this association modulated by extracellular triggers and BCR aggregation. CD20 remains on the cell surface after receptor ligation and serves as a therapeutic target for antibody-mediated B-cell depletion. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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