Thermo Fisher Scientific RNF7 Polyclonal Antibody
RNF7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 인간 및 생쥐 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포주기 조절 및 단백질 분해 연구에 활용됩니다.
- 카탈로그번호
- PA550872
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length fusion protein of Human RNF7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636324 |
Product Specific Information
The antibody detects endogenous levels of total RNF7 protein.
Target Information
The RNF7 gene encodes a highly conserved ring finger protein that functions as an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are critical for protein degradation related to cell cycle progression and signal transduction.
This protein interacts with and is a substrate of casein kinase II (CSNK2A1/CKII). Phosphorylation by CSNK2A1 promotes degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1 (CDKN1B).
Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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