Thermo Fisher Scientific MICA Monoclonal Antibody (6)

Applications

ELISA

• Tested Dilution: 1:1,000–1:2,000
• Publications: -

Product Specifications

Product Specific Information

• This product is preservative free.
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
• This antibody has specificity for Human MICA.

Target Information

Major histocompatibility complex (MHC) class I proteins are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells.
A related family, termed the MHC class I chain-related (MIC) proteins, are recognized by NKG2D—a receptor on NK and T cells—and promote anti-tumor activity.
MICA, a member of the MIC family, is widely expressed on many tumors, and the MICA/NKG2D interaction is thought to stimulate anti-tumor reactivity by T lymphocytes.
Both MICA and MICB mRNA are widely expressed in normal tissues, with MICA being present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.