Thermo Fisher Scientific Phospho-PKR (Thr446) Polyclonal Antibody
인간 PKR(Thr446) 인산화 형태를 검출하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS 기반의 안정적 액상 형태로 제공되며, 바이러스 감염 및 세포 스트레스 연구에 활용 가능.
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-PKR (Thr446) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide corresponding to residues around human PKR (phospho Thr446). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901993 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses.
PKR plays a key role in antiviral defense mediated through its activation by double-stranded RNA produced during viral infection. It is involved in IFN-induced innate antiviral response, virus-induced apoptosis, cell growth, and differentiation.
PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling. Upon viral infection, PKR functions as a dual protein, sequentially activating both cell survival and cell death pathways through kinase-independent and -dependent mechanisms.
It regulates multiple pathways including NF-kappaB, p53, p38, and PDGF signaling, and has been implicated in tumor suppression and malignancy.
To evade PKR’s antiviral effects, viruses have evolved mechanisms such as inhibition by influenza virus NS1 protein. PKR is also associated with several neurodegenerative diseases including Alzheimer’s, Huntington’s, and amyotrophic lateral sclerosis.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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