Thermo Fisher Scientific LDL receptor Polyclonal Antibody

Thermo Fisher Scientific LDL receptor Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution

• 1:500–1:3,000

Publications

• [References not provided]

Product Specifications

Product Specific Information

• Centrifuge briefly prior to opening.

Target Information

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands.
Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell, ending up in lysosomes where the protein is degraded and cholesterol becomes available for repression of HMG CoA reductase—the rate-limiting enzyme in cholesterol synthesis.
Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder.
Along with SCARB1, CLDN1, and CD81, LDL-R has been reported to act as an entry factor for the Hepatitis C virus.
At least three isoforms of LDL-R are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.