Thermo Fisher Scientific LDL receptor Polyclonal Antibody
인간 LDL 수용체를 인식하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 장기 보관을 위해 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific LDL receptor Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution
- 1:500–1:3,000
Publications
- [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of Human LDL Receptor (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.03 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901995 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands.
Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell, ending up in lysosomes where the protein is degraded and cholesterol becomes available for repression of HMG CoA reductase—the rate-limiting enzyme in cholesterol synthesis.
Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder.
Along with SCARB1, CLDN1, and CD81, LDL-R has been reported to act as an entry factor for the Hepatitis C virus.
At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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