Thermo Fisher Scientific LDL receptor Polyclonal Antibody
Thermo Fisher Scientific의 LDL receptor Polyclonal Antibody는 인간 LDL 수용체를 인식하는 토끼 유래 IgG 항체로, Western blot에 최적화되어 있습니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1:500–1:3,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of Human LDL Receptor (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.66 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | −20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901994 |
Product Specific Information
Centrifuge briefly prior to opening.
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL binds to the cell membrane and is internalized into lysosomes, where the protein is degraded and cholesterol becomes available to repress HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder. LDL-R, along with SCARB1, CLDN1, and CD81, has been reported as an entry factor for Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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