Thermo Fisher Scientific TET2 Polyclonal Antibody
TET2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western Blot과 ELISA에 적합하며, 고농도(72.5 mg/mL) 액상 형태로 제공됩니다. -20°C에서 보관하며 동결·해동 반복은 피해야 합니다.
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- 100-401-N93x (2개 옵션)
- 판매단위
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TET2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| ELISA | 1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | TET2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a human TET-2 domain containing the N-terminal 156 amino acids of the protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 72.5 mg/mL |
| Storage Buffer | 0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.
It is directed against, and shows specific reactivity for human Tet2 protein.
Cross reactivity with Tet1 and Tet3 has not been determined.
Target Information
TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation.
TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and 5fC to 5-carboxylcytosine (5caC).
Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytosine demethylation.
In addition to TET2’s role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase (OGT) to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Mutations in the gene can result in Polycythemia vera and Myelodysplastic syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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