Thermo Fisher Scientific MEKK1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MEKK1 (MAP3K1) C-terminal region. Validated for Western blot applications. Supplied as liquid at 0.5 mg/mL in PBS with sucrose and sodium azide. Suitable for MAPK pathway research. For research use only.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human MAP3K1 (aa 1251–1300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607952 |
Product Specific Information
Peptide sequence:
LGAFSSCYQA QDVGTGTLMA VKQVTYVRNT SSEQEEVVEA LREEIRMMSH
Sequence homology:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MEKK1 phosphorylates and activates MAPKK 1 and MAPKK 2 (MEK1/MEK2), leading to phosphorylation of MAP kinases.
It is also an efficient activator of the JNK cascade and contains a putative RING-type zinc finger and SWIM-type zinc finger.
These kinases are highly conserved across species including yeast, Drosophila, and mammals.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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