Thermo Fisher Scientific CD107b (LAMP-2) Monoclonal Antibody (GL2A7), FITC
FITC 형광 표지된 CD107b (LAMP-2) 단클론 항체로 인간, 마우스, 토끼 시료에 반응. 단백질 G 정제 및 보존제 무첨가. WB, ICC/IF, IP 등 다양한 응용 가능. 4°C 암소 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:500 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rabbit |
| Host / Isotype | Rat / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GL2A7 |
| Immunogen | Purified preparation of mouse liver lysosomal membranes |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | 9.1 mM sodium bicarbonate/PBS (pH 7.4) with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage conditions | 4°C, store in dark |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931624 |
Additional Formats
- APC (MA5-45169)
- PerCP (MA5-45171)
- Request custom conjugation
Product Specific Information
1 µg/mL of MA5-45170 was sufficient for detection of LAMP2 in 20 µg of rat liver microsomes by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 100–110 kDa.
Target Information
LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a lysosomal membrane glycoprotein involved in lysosome biogenesis and fusion with phagosomes. It plays roles in tumor cell metastasis, lysosomal maintenance, and chaperone-mediated autophagy.
Prior to posttranslational modification, LAMP2 is a 46 kDa polypeptide; the mature form is 100–130 kDa due to extensive glycosylation.
LAMP2 has three variant forms (LAMP-2A, -2B, -2C) and, together with LAMP-1 (CD107a), constitutes major lysosomal membrane components.
Deficiency in LAMP2 leads to accumulation of autophagosomes, resulting in cardiomyopathy and myopathy (Danon’s disease).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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