Thermo Fisher Scientific DNMT2 Polyclonal Antibody
DNMT2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 인간 단백질에 반응하며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DNMT2. Recombinant protein control fragment (Product # RP-102756) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640730 |
Product Specific Information
Immunogen sequence:
RVLELYSGVG GMHHALRESC IPAQVVAAID VNTVANEVYK YNFPHTQLLA KTIEGITLEE FDRLSFDMIL MSPPCQPFTR IGRQGDMTDS RT
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 86%
Target Information
CpG methylation is an epigenetic modification important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein similar to DNA methyltransferases, though it lacks methyltransferase activity. The protein binds DNA strongly, suggesting a role in marking specific genomic sequences. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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