Thermo Fisher Scientific Fibronectin Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total Fibronectin.

Target Information

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble protein extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. It is most abundant during embryonic development and tissue remodeling, and also found as a soluble plasma protein.

Fibronectin consists of repeating modules forming domains for interactions with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins). It plays key roles in cell adhesion, migration, wound healing, blood coagulation, host defense, and metastasis.

Fibronectin expression is increased in non-small cell lung carcinoma, where its adhesion enhances tumorigenicity and confers resistance to chemotherapy-induced apoptosis. The FN1 gene has three regions subject to alternative splicing, potentially generating up to 20 transcript variants, though not all are fully characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.