Thermo Fisher Scientific PIASy Polyclonal Antibody
PIASy 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며, Affinity chromatography로 정제되었습니다. SUMO ligase 관련 연구 및 신호전달 경로 분석에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PIAS4 (Accession Q8N2W9), corresponding to amino acid residues L468–C510 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818388 |
Product Specific Information
Antibody detects endogenous levels of total PIAS4.
Target Information
PIAS4 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and its substrates, and acts as a SUMO-tethering factor. It plays a key role as a transcriptional coregulator in multiple signaling pathways, including STAT, p53/TP53, Wnt, and steroid hormone pathways. It is involved in gene silencing and mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4, and RNF168. In Wnt signaling, it represses LEF1 and enhances TCF4 transcriptional activities by promoting their sumoylation. It also enhances MTA1 sumoylation and may participate in paralog-selective sumoylation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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