Thermo Fisher Scientific Interleukin-3 (IL-3) Monoclonal Antibody (IL3/4005)
인간 IL-3를 인식하는 Mouse monoclonal 항체로, IHC(P), IHC(PFA) 등 다양한 응용에 사용 가능. 단백질 A/G 정제 및 PBS 완충액에 보관. 4°C에서 보관하며 동결 금지. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | - |
| Peptide Array (Array) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL3/4005 |
| Immunogen | Recombinant fragment of human IL3 protein (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin 3 (IL-3), also known as Mast Cell Growth Factor (MCGF), Multi-Colony Stimulating Factor (multi-CSF), or Eosinophil-CSF (E-CSF), is produced by activated T cells, mast cells, and eosinophils.
IL-3 is a hematopoietic growth factor that stimulates colony formation of erythroid, megakaryocyte, neutrophil, eosinophil, basophil, mast cell, and monocytic lineages.
Most of these functions are enhanced or dependent on co-stimulation with other cytokines. Human and mouse IL-3 share only 29% sequence identity at the amino acid level, and the bioactivity of IL-3 is highly species-specific. For example, human IL-3 has no activity on mouse cells.
IL-3 supports proliferation of a wide range of hematopoietic cell types and is involved in cell growth, differentiation, and apoptosis. It also exhibits neurotrophic activity and may be associated with neurological disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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