Thermo Fisher Scientific UBR4 Polyclonal Antibody
UBR4 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 IHC(P)에서 검증됨. 인간, 마우스, 랫트에 반응하며, Rabbit IgG로 제작됨. 액상 형태로 1 mg/mL 농도, PBS와 50% 글리세롤 용액에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human UBR4 (Accession Q5T4S7), corresponding to amino acid residues P4006–A4056 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900735 |
Product Specific Information
This antibody detects endogenous levels of total UBR4.
Target Information
UBR4 is an E3 ubiquitin-protein ligase that functions in the N-end rule pathway. It recognizes and binds to proteins with destabilizing N-terminal residues, leading to their ubiquitination and degradation. Together with clathrin, UBR4 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. It also regulates integrin-mediated signaling and may play a role in FAK activation in response to cell-matrix interactions. Additionally, UBR4 mediates ubiquitination of ACLY, resulting in its degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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