Thermo Fisher Scientific Human ATG13 Synthetic Peptide
인간 ATG13 단백질의 C-말단 15개 아미노산을 기반으로 한 합성 펩타이드입니다. ATG13 항체(PA5-20999)와 함께 차단 실험에 사용 가능합니다. 오토파지 연구용으로 적합하며, PBS/BSA 완충액에 보관됩니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP1113
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human ATG13 Synthetic Peptide
Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human ATG13.
PEP-1113 can be used as a blocking peptide with polyclonal antibody PA5-20999.
Target Information
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components.
This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1, and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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