Thermo Fisher Scientific Phospho-MEK1 (Ser218, Ser222) Polyclonal Antibody
Phospho-MEK1 (Ser218, Ser222) 폴리클로날 항체로 MAPK 신호전달 연구에 적합. Western blot, IHC, Dot blot 등 다양한 응용 가능. Rabbit IgG 기반, 고순도 정제 및 안정적 저장. 인산화 MEK1 검출용 연구 전용 항체.
- 카탈로그번호
- PA512624
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Dot Blot (DB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S218/222 of human MEK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981190 |
Product Specific Information
This antibody is predicted to react with chicken, canine, equine, hamster, mouse, rat, rabbit, and Xenopus based on sequence homology.
Target Information
MAP2K1 (MEK1) kinase is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. MEK1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in signaling during stress-activated response, apoptosis, and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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