Thermo Fisher Scientific TMC1 Polyclonal Antibody

Thermo Fisher Scientific TMC1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute with 100 µL of distilled water.
The peptide is homologous in mouse.

Target Information

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat.
The SLP-76 locus is localized to human chromosome 5q33 and partially characterized in mice.
Human and murine cDNAs encode 533 amino acid proteins that are 72% identical, comprising three modular domains:

• NH2-terminus: acidic region with a PEST domain and tyrosine residues phosphorylated after TCR ligation
• Central: proline-rich domain
• COOH-terminus: SH2 domain

SLP-76 interacts with multiple proteins both constitutively and inducibly following receptor ligation, functioning as an adaptor or scaffold protein.
Studies using SLP-76 deficient T cell lines or mice demonstrate its role in T cell development, activation, mast cell, and platelet function.

Additional Information

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.