Thermo Fisher Scientific TMC1 Polyclonal Antibody
TMC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western Blot 및 Immunohistochemistry에 사용 가능. 합성 human TMC1 펩타이드를 면역원으로 사용. 연구용으로만 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지.
- 카탈로그번호
- OST00104W
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific TMC1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human TMC1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C and avoid freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2204070 |
Product Specific Information
Reconstitute with 100 µL of distilled water.
The peptide is homologous in mouse.
Target Information
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat.
The SLP-76 locus is localized to human chromosome 5q33 and partially characterized in mice.
Human and murine cDNAs encode 533 amino acid proteins that are 72% identical, comprising three modular domains:
- NH2-terminus: acidic region with a PEST domain and tyrosine residues phosphorylated after TCR ligation
- Central: proline-rich domain
- COOH-terminus: SH2 domain
SLP-76 interacts with multiple proteins both constitutively and inducibly following receptor ligation, functioning as an adaptor or scaffold protein.
Studies using SLP-76 deficient T cell lines or mice demonstrate its role in T cell development, activation, mast cell, and platelet function.
Additional Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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