Thermo Fisher Scientific TMC6 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000
• Publications: 참고 문헌 보기

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000
• Publications: 참고 문헌 보기

Miscellaneous PubMed (Misc)

• Publications: View 5 publications

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: TMC6.

Target Information

TMC6 interacts with and forms a complex with the zinc transporter 1, SLC30A1, and localizes to the endoplasmic reticulum, nuclear membrane, and Golgi apparatus.
Inactivation of the TMC6 gene is implicated in epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and high progression rate to squamous cell carcinoma on sun-exposed skin.
EV is caused by mutations in two adjacent genes located on chromosome 17q25.3. TMC6 encodes integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs.
Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.