Thermo Fisher Scientific TMC6 Polyclonal Antibody
TMC6 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합. 합성 펩타이드 항원으로 제작되어 높은 특이성 제공. Lyophilized 형태로 보관 용이하며, 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
- Publications: 참고 문헌 보기
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
- Publications: 참고 문헌 보기
Miscellaneous PubMed (Misc)
- Publications: View 5 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the 2d cytoplasmic loop of human transmembrane channel-like protein 6 (TMC6, EVER1, Protein LAK-4, EVIN1) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TMC6.
Target Information
TMC6 interacts with and forms a complex with the zinc transporter 1, SLC30A1, and localizes to the endoplasmic reticulum, nuclear membrane, and Golgi apparatus.
Inactivation of the TMC6 gene is implicated in epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and high progression rate to squamous cell carcinoma on sun-exposed skin.
EV is caused by mutations in two adjacent genes located on chromosome 17q25.3. TMC6 encodes integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs.
Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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