Thermo Fisher Scientific MPZ Polyclonal Antibody

Applications

• Western Blot (WB): 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

• Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Myelin Protein Zero (MPZ) is a type I integral membrane glycoprotein that mediates adhesion of myelin sheath layers, ensuring stable synaptic transmission. It constitutes approximately 50% of the total protein in peripheral myelin, contributing to structural integrity. MPZ facilitates compact myelin wrapping through glycine zipper–dependent dimer and tetramer formation. Mutations such as G134R may disrupt multimer formation, leading to demyelinating neuropathies including Charcot-Marie-Tooth disease. The cytoplasmic domain undergoes serine and tyrosine phosphorylation, particularly during peak nerve myelination. Expression is moderate in brain, abundant in thymus, and highest in CNS white matter.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.