Thermo Fisher Scientific MAGE1 Polyclonal Antibody
MAGE1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체로, Western blot 및 IHC(P) 검증 완료. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 종양 항원 연구 및 암 면역치료 연구용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 280–309 of Human MAGE-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4 °C short term. For long-term storage, store at −20 °C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553352 |
Product Specific Information
This antibody detects endogenous levels of MAGE-1 protein at molecular weights of approximately 34 kDa and 46 kDa, and also detects endogenous levels of Tumor antigen MAGE-N.
Purity is >95% by SDS-PAGE.
Target Information
Human malignant neoplasms carry rejection antigens recognized by autologous, tumor-directed, and specific cytolytic CD8⁺ T lymphocyte clones (CTLs). An important group of these antigens is coded by the MAGE family of genes.
MAGE-1 is expressed in a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, and renal cell carcinomas) but not in normal tissues. Therefore, the encoded antigen may serve as a marker for early detection and a target for cancer immunotherapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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