Thermo Fisher Scientific MHC Class I Recombinant Rat Monoclonal Antibody (R1-9.6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is specific for murine MHC class I and binds to polymorphic H-2 determinants expressed on most haplotypes. It can bind all H-2 class I molecules, independent of allele, and recognizes a determinant distinct from those detected by most common mouse monoclonal anti-H-2 antibodies.

Target Information

Like their mammalian counterparts, avian MHC Class I molecules (also known as B-F antigens) consist of a highly polymorphic alpha-chain noncovalently bound to the invariant beta2-microglobulin subunit. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, typically cytotoxic T cells. The monoclonal antibody F21-2 also reacts with turkey MHC Class I.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.