Thermo Fisher Scientific HRD1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human HRD1. Recombinant protein control fragment (Product #RP-89211). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HRD1,uniProtId:Q86TM6-1,ncbiNodeId:9606,antigenRange:238-353,antigenLength:617,antigenImageFileName:PA5-110899_HRD1_Q86TM6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-110899_HRD1_Q86TM6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2856310

Product Specific Information

Immunogen sequence: HTFPLFAIRP MYLAMRQFKK AVTDAIMSRR AIRNMNTLYP DATPEELQAM DNVCIICREE MVTGAKRLPC NHIFHTSCLR SWFQRQQTCP TCRMDVLRAS LPAQSPPPPE PADQGP

Target Information

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.