Thermo Fisher Scientific CSF1R Polyclonal Antibody
CSF1R 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며 고순도 친화 크로마토그래피로 정제되었습니다. PBS/50% glycerol buffer에 보관되며, 세포 내 CSF1R 발현 연구에 유용합니다.
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Thermo Fisher Scientific CSF1R Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CSF1R (Accession P07333), corresponding to amino acid residues A800–S850 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900193 |
Product Specific Information
Antibody detects endogenous levels of total MCSF Receptor.
Target Information
CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation.
CSF1R is a tyrosine kinase transmembrane receptor and a member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the CSF1R gene are associated with a predisposition to myeloid malignancy.
This receptor plays an essential role in the regulation of survival, proliferation, and differentiation of hematopoietic precursor cells, especially macrophages and monocytes. It promotes the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammatory processes.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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