Thermo Fisher Scientific CSF1R Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total MCSF Receptor.

Target Information

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation.
CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases.
Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.
This receptor acts as a cell-surface receptor for CSF1 and IL34, playing an essential role in the regulation of survival, proliferation, and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes such as macrophages and monocytes.
It promotes the release of proinflammatory chemokines in response to IL34 and CSF1 and plays an important role in innate immunity and inflammatory processes.
The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-115557_CSF1R_CD115_P07333-1_Rabbit.svg, PA5-115557_CSF1R_CD115_P07333-1_Rabbit_PDP.jpeg)