Thermo Fisher Scientific CCBL1 Polyclonal Antibody
CCBL1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, ICC/IF, ELISA에 적합하며 Human, Mouse, Rat에 반응. 고순도 Affinity Chromatography 정제 및 PBS/glycerol buffer 보존. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:10–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–270 of human CCBL1 (NP_001116144.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.69 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2854896 |
Product Specific Information
Immunogen sequence:
MAKQLQARRL DGIDYNPWVE FVKLASEHDV VNLGQGFPDF PPPDFAVEAF QHAVSGDFML NQYTKTFVII IEPFFDCYEP MTMMAGGRPV FVSLKPGPIQ NGELGSSSNW QLDPMELAGK FTSRTKALVL NTPNNPLGKV FSREELELVA SLCQQHDVVC ITDEVYQWMV YDGHQHISIA SLPGMWERTL TIGSAGKTFS ATGWKVGWVL GPDHIMKHLR TVHQNSVFHC PTQSQAAVAE SFEREQLLFR QPSSYFVQFP QAMQRCRDHM
Target Information
Kynurenine aminotransferases (KAT I, KAT II, and KAT III) belong to the class-I pyridoxal-phosphate-dependent aminotransferase family.
KAT I is a cytoplasmic protein involved in glutamine catabolism and catalyzes the transamination of L-kynurenine to form kynurenic acid, a neuroprotective and anticonvulsant metabolite of tryptophan.
Kynurenic acid participates in synaptic transmission and has been implicated in neurological disorders such as schizophrenia and Huntington’s disease.
KAT I also metabolizes cysteine conjugates of halogenated alkenes and alkanes to form reactive metabolites.
KAT I has three isoforms:
- Isoform 1: full-length protein
- Isoform 2: lacks amino acids 68–117
- Isoform 3: lacks amino acids 251–422
Based on sequence similarity, KAT I is thought to function as a homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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