Thermo Fisher Scientific TGF beta-3 Polyclonal Antibody
TGF beta-3에 특이적인 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 생쥐 반응성을 갖습니다. WB와 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 세포 신호전달 및 면역반응 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000–1:20,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human TGF beta 3 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736699 |
Product Specific Information
- Positive Control: human-TGFB3 transfected 293T
- Predicted Reactivity: Rat (97%), Pig (91%), Chicken (87%), Rhesus Monkey (100%), Bovine (87%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, including TGF beta 1 and beta 2. These cytokines are secreted in precursor form, consisting of a bioactive C-terminal domain attached to an N-terminal latency associated protein (LAP). Cleavage of LAP results in the mature disulfide-linked homodimer protein.
TGF beta 3 is highly conserved across species, showing 100% sequence homology between mouse and human. Members of this family are expressed by most cell types and exert pleiotropic effects such as:
- Suppression of B- and T-cell effector activity
- Mediation of tissue healing
- Suppression of tumor proliferation
- Promotion of CD4+CD25+ T-cell expansion, indicating a role in protection against autoimmunity
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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