Thermo Fisher Scientific alpha Adaptin Monoclonal Antibody (AP6), Alexa Fluor 555

Thermo Fisher Scientific alpha Adaptin Monoclonal Antibody (AP6), Alexa Fluor 555

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: 5 µg/mL

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 647
• Request custom conjugation

Product Specific Information

MA1-064A555 detects assembly polypeptide 2 (AP2) from a wide variety of mammalian sources, including human, hamster, monkey, bovine, rat, and mouse.
It recognizes the products of both alpha-adaptin genes, alpha A and alpha C, as well as an alternatively spliced isoform of alpha adaptin found in neurons.

Target Information

Component of the adaptor protein complex 2 (AP-2).
Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways.
AP-2 is involved in clathrin-dependent endocytosis, facilitating cargo selection and vesicle formation.
It serves as a cargo receptor to selectively sort membrane proteins involved in receptor-mediated endocytosis and plays a role in recycling synaptic vesicle membranes.
The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane and acting as a scaffolding platform for endocytic accessory proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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