Thermo Fisher Scientific Desmin Monoclonal Antibody (D9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:1,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

-

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:25-1:200

-

Immunohistochemistry (Frozen) (IHC (F))

1:25-1:200

-

Miscellaneous PubMed (Misc)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Chicken, Human, Mouse, Pig, Rabbit, Rat

Published species

Human, Pig, Rat, Rhesus monkey

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

D9

Immunogen

Desmin isolated from human leiomyoma. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Desmin,uniProtId:P17661-1,ncbiNodeId:9606,antigenRange:1-470,antigenLength:470,antigenImageFileName:MA1-06401_Desmin_P17661-1_House_mouse.svg,antigenImageFileNamePDP:MA1-06401_Desmin_P17661-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

purified

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_558631

Product Specific Information

MA1-06401 detects desmin in human, mouse, rat, rabbits, pig, and chicken samples.

MA1-06401 has sucessfully been used in Western blotting, and immunohistochemistry. By Western blotting, it detects a ~53 kDa protein representing desmin.

The MA1-06401 immunogen is desmin isolated from human leiomyoma.

Target Information

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.