Thermo Fisher Scientific STIM2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

In T lymphocytes, the sole pathway for Ca²⁺ entry following antigen-receptor binding is through store-operated Ca²⁺-release-activated Ca²⁺ (CRAC) channels. These channels consist of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), which acts as a Ca²⁺ sensor and activates CRAC channels by migrating to the plasma membrane from ER-like Ca²⁺ stores.
A related molecule, STIM2, inhibits STIM1-mediated store-operated Ca²⁺ entry and can form complexes with STIM1, suggesting a coordinated role in Ca²⁺ regulation. At least three isoforms of STIM2 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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