Thermo Fisher Scientific SPRY2 Recombinant Rabbit Monoclonal Antibody (10M8H1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10M8H1

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 216-315 of human Sprouty 2 (O43597). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SPRY2,uniProtId:O43597-1,ncbiNodeId:9606,antigenRange:216-315,antigenLength:315,antigenImageFileName:MA5-42888_SPRY2_O43597-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42888_SPRY2_O43597-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912029

Product Specific Information

Positive test controls include: C6.

Immunogen sequence: GTCVCCVKGL FYHCSNDDED NCADNPCSCS QSHCCTRWSA MGVMSLFLPC LWCYLPAKGC LKLCQGCYDR VNRPGCRCKN SNTVCCKVPT VPPRNFEKPT

Target Information

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.