Thermo Fisher Scientific Connexin 46 Recombinant Rabbit Monoclonal Antibody (11H16L33)
Connexin 46 단백질을 표적하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. WB, IHC 등 다양한 응용에 적합하며 높은 특이성과 일관된 로트 간 품질을 제공. Expi293 시스템에서 생산된 동물 유래 성분 없는 항체로 장기 안정성 우수.
- 카탈로그번호
- 700384
- 판매단위
- pk
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Thermo Fisher Scientific Connexin 46 Recombinant Rabbit Monoclonal Antibody (11H16L33)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC-P) | 0.5–2 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC-F) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 11H16L33 |
| Immunogen | Peptide corresponding to amino acids 131–144 of Q64448 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at –20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532318 |
Product Specific Information
- Predicted to react with rat and hamster based on sequence homology.
- Intact IgG appears on a non-reducing gel as ~150 kDa band; upon reduction, generates ~25 kDa light chain and ~50 kDa heavy chain bands.
- Recombinant rabbit monoclonal antibodies are produced via in vitro expression systems using cloned antibody DNA sequences from immunoreactive rabbits.
- Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to rabbit immune repertoire
Target Information
Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46, and C2P3, maps to human chromosome 13q11–q12 and encodes a 46 kDa protein.
Cx46, together with Cx50, is principally expressed in the lens of the eye and mediates intercellular interactions essential for lens transparency and normal function.
Mutations in Cx46 cause severe cataracts. Knockouts of Cx46 and Cx50 affect lens fiber cell differentiation and size, indicating their cooperative role in lens organization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: 700384_Connexin_46_Q64448-1_Rabbit.svg, 700384_Connexin_46_Q64448-1_Rabbit_PDP.jpeg)
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