Thermo Fisher Scientific Phospho-NFkB p50/p105 (Ser923) Polyclonal Antibody
Rabbit 유래의 polyclonal antibody로, NFkB p50/p105의 Ser923 인산화 부위를 인식합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 세포 성장·분화·염증 관련 연구에 적합합니다. 액상 형태로 -20°C 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NF-kB p105 around the phosphorylation site of Ser923 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903105 |
Target Information
NF-kB is a nuclear transcription factor activated by various extracellular and intracellular stimuli such as cytokines, UV radiation, stress, injury, and microbial products. It regulates key cellular processes including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa functional subunit of NF-kB, belongs to the Rel protein family. It is synthesized as a p105 precursor containing an N-terminal conserved RHD region with nuclear localization, DNA-binding, and dimerization domains. NFKB1 (p50) can form homodimers or heterodimers with p65 to constitute the functional NF-kB complex, facilitating nuclear translocation and DNA binding.
NF-kB has been implicated in various pathological conditions such as AIDS, hematogenic cancer metastasis, and rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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